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Roland E Dolle Selected Research

piperidine

9/2012δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.
9/2009Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
10/2008Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

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Roland E Dolle Research Topics

Disease

5Pain (Aches)
09/2012 - 08/2006
2Obesity
08/2014 - 11/2007
2Neuralgia (Stump Neuralgia)
09/2012 - 10/2009
2Chronic Pain
09/2012 - 01/2009
2Inflammation (Inflammations)
01/2009 - 08/2006
1Type 2A Charcot-Marie-Tooth disease
01/2020
1Substance-Related Disorders (Drug Abuse)
08/2014
1Parkinson Disease (Parkinson's Disease)
06/2011
1Dyskinesias (Dyskinesia)
06/2011
1Chorea (Rheumatic Chorea)
06/2011
1Dystonia (Limb Dystonia)
06/2011
1Pruritus (Itching)
11/2007
1Respiratory Insufficiency (Respiratory Failure)
11/2007
1Opioid-Induced Constipation
11/2007
1Tardive Dyskinesia
11/2007
1Ileus
11/2007
1Otitis
08/2006
1Hyperalgesia
08/2006

Drug/Important Bio-Agent (IBA)

3benzamideIBA
09/2012 - 10/2008
3N,N- diethyl- 4- (5- hydroxyspiro(chromene- 2,4'- piperidine)- 4- yl)benzamideIBA
09/2012 - 10/2008
3piperidineIBA
09/2012 - 10/2008
3BenzopyransIBA
09/2012 - 10/2008
2alvimopanFDA Link
08/2014 - 11/2007
2N,N- diethyl- 3- hydroxy- 4- (spiro(chromene- 2,4'- piperidine)- 4- yl)benzamideIBA
09/2012 - 09/2009
2Opioid Analgesics (Opioids)IBA
09/2012 - 11/2007
2delta Opioid Receptors (delta Opioid Receptor)IBA
09/2009 - 10/2008
1Proteins (Proteins, Gene)FDA Link
01/2020
1NicotineFDA Link
08/2014
1Narcotic Antagonists (Opioid Antagonists)IBA
08/2014
1Cocaine (Cocaine HCl)IBA
08/2014
1LY 243670IBA
08/2014
1Freund's AdjuvantIBA
09/2012
14- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- methoxybenzyl)- N,N- diethylbenzamideIBA
09/2012
1Analgesics (Analgesic Drugs)IBA
09/2012
1Dihydrotachysterol (AT 10)IBA
06/2011
1Dihydroxyphenylalanine (Dopa)IBA
06/2011
1Levodopa (L Dopa)FDA LinkGeneric
06/2011
1mu Opioid Receptors (mu Opioid Receptor)IBA
06/2011
1Naltrexone (ReVia)FDA LinkGeneric
06/2011
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
06/2011
12,2- dimethyl- N- (5- methyl- 4- (morpholinomethyl)pyridin- 2- yl)butanamideIBA
10/2009
1compound 20IBA
10/2008
1Morphine (MS Contin)FDA LinkGeneric
11/2007
1methylnaltrexoneFDA Link
11/2007
1Nitric Oxide Synthase (NO Synthase)IBA
08/2006
1Acetic Acid (Vinegar)FDA LinkGeneric
08/2006
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2006
1Arachidonic Acid (Vitamin F)IBA
08/2006
1Protein Isoforms (Isoforms)IBA
08/2006

Therapy/Procedure

2Ligation
09/2012 - 08/2006
2Therapeutics
01/2009 - 11/2007
1Drug Therapy (Chemotherapy)
08/2014
1Oral Administration
10/2009
1Pain Management
11/2007
1Operative Surgical Procedures
08/2006